The QBio is led by a Director, Joe Howard, Eugene Higgins Professor of Molecular Biophysics & Biophysics, and Professor of Physics.

Governance and oversight are provided by an Advisory Committee, whose authority includes recommending faculty appointments to the Institute. The Advisory Committee comprises Tom Appelquist (Physics), Jeff Brock(Mathematics; Dean of Science; Dean of Engineering and Applied Science), Thierry Emonet (Molecular, Cellular & Developmental Biology; Physics), Jay Humphrey (Biomedical Engineering),  Megan King  (Cell Biology; Molecular, Cellular & Development Biology; Yale Cancer Center), Ruth Montgomery (Rheumatology; Associate Dean for Scientific Affairs, Yale School of Medicine), Tom Pollard (Molecular, Cellular & Developmental Biology; Molecular Biophysics & Biophysics; Cell Biology), Scott Strobel (Molecular Biophysics & Biophysics; Chemistry, Vice Provost for Science Initiatives), and Gunter Wagner (Ecology & Evolutionary Biology; Obstetrics, Gynecology and Reproductive Sciences).